Salvia Sclarea and Ambroxene: Part Two
In the first part, the development of ambergris and ambroxene is introduced, and at the end, the best natural ambergris substitute raw material perilla is mentioned.
The most valuable industrial application is Ambroxane which is synthesized from salvia sclarea. China had rich Salvia aclarea resources,the wild natural plant was found abundantly grow in Henan, Shaanxi, and after people learn the market potential of Salvia scarea, artificial cultivation is also developed.
Perillyl alcohol extracted from the salvia scarea, which is rich in natural resources, has a similar carbon atom formula structure ambroxene. The structure also has a chiral center similar to that of ambroxene. The most ingenious part is that the configuration they commonly possessed is the key to the outstanding aroma of such molecules.
The process of synthesizing salvia sclarea is mainly divided into three stages: Sclareol undergoes side chain oxidation through oxidizing agent to produce sclareolide, which is then reduced to produce ambradiol. Finally, under the action of organic acid, sulfonyl chloride or lewis acid, it is dehydrated and cyclized to produce ambroxene. In the three stages, the current research around the world mainly focuses more on the selection of oxidants for oxidative degradation of sclareol side chains. Although perillyl alcohol has been used as a raw material to realize the industrial production of ambroxene, people are still exploring better oxidants and better synthetic process routes. Please contact [email protected] for more knowledge about our ambroxene.