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  • Red Yeast Rice Dosage
    May 04, 2022

    Product description

    Use

    M. purpureus is a natural source of mevinolin, the active ingredient of the drug lovastatin, therefore, having beneficial effects in the treatment of hyperlipidemia. However, red yeast rice should not be used in place of lovastatin and regular medical care because of potential product safety concerns related to dietary supplements, and lack of patient monitoring. Evidence also exists for its antibacterial and anticancer effects, as well as its activity on glycemic metabolism.

    Dosing

    Red yeast rice is available commercially, primarily as a 600 mg capsule. Most manufacturers suggest an oral dosage of 2 capsules twice a day for a total dose of 2,400 mg/day. Commercial over-the-counter products often contain coenzyme Q10 to supplement low levels of this enzyme in patients with statin myopathy. Clinical trials have used dosages of 1,200 to 3,600 mg/day.

    Contraindications

    Hypersensitivity to any components of red yeast rice. Anaphylactic reactions in certain populations are documented. Because red yeast rice depletes tissue of coenzyme Q10, which may increase the risk of statin-induced myopathy, patients with muscle damage caused by statins should avoid its use.

    Pregnancy/Lactation

    Avoid use during pregnancy and lactation. One ingredient in red yeast rice is monacolin K, which is also known as mevinolin or lovastatin and has statin-like activity. Statins are potential teratogens based on theoretical considerations and small case studies. CNS and limb defects have been reported in newborns exposed to statins in utero.

    Interactions

    There are many possible drug interactions associated with red yeast rice. Consult a health care provider before using any dietary supplement.

    Adverse Reactions

    Meta-analysis of the efficacy of 3 red yeast rice preparations (Cholestin, Xuezhikang, and Zhibituo) from 93 randomized trials (9,625 patients) documented no serious adverse reactions. The most common adverse reactions included dizziness, decreased appetite, nausea, stomachache, abdominal distension, and diarrhea. A small number of patients experienced increased serum blood urea nitrogen (BUN) and ALT levels. A meta-analysis showed incidence of liver injury, kidney injury, and muscle symptoms with red yeast rice products was not significantly different compared to control.

    Toxicology

    The nephrotoxic mycotoxin citrinin has been isolated from some strains of M. purpureus and Monascus ruber. No severe toxicities at high doses have been reported. Not recommended for use in patients with liver or kidney disease.

    Company profile

    Founded in 2002 when organic concept is not as popular as today, we are one of earliest organic food ingredients suppliers in China, In 18 years, we put our best passion and endeavour in this field from a small-scale factory to a company. Staying true in the mission to provide organic health food ingredients and natural lifestyle to people, which being why we keep evolving for nearly 20 years.

    Certificate

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    Packing and transport

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