Chemically, curcumin is a diarylheptanoid, belonging to the group of curcuminoids, which are natural phenols responsible for turmeric' yellow color. It is mainly used as an herbal supplement, cosmetics ingredient, food flavoring and food coloring.
What are the main medicinal values of curcumin?
1 Blood-lipid lowering effect
Curcumin has the function of reducing plasma total cholesterol, β-lipoprotein, triglycerides and hepatic cholesterol, and balancing the proportion of α-and β-lipoprotein, but it has no effect on endogenous cholesterol. Studies have shown that curcumin can inhibit the synthesis of fatty acids.
2 Anti-inflammatory effect
Curcumin can antagonize the swelling of rat toes induced by anti-angle-nectarine in a dose-dependent manner in the range of 30 mg/kg, while it inhibits this anti-inflammatory effect in the dose of 60 mg/kg . Curcumin sodium reversibly inhibits isolated guinea pig ileum contraction induced by nicotine, acetylcholine, serotonin, barium chloride and histamine, similar to non-steroidal anti-inflammatory drugs.
3 Anti-pathogenic microorganisms effect
In vitro test, curcumin inhibit micrococcus when it is in 1% concentration.
4 The effect on the cardiovascular system
Curcumin intravenous injection has no significant effect on blood pressure, and also has no significant effect on blood pressure induced by adrenaline, histamine and acetylcholine. Curcumin can antagonize the changes of S-T and T-wave in rat electrocardiogram induced by intravenous injection of pituitrin, and also can increase the nutrient blood flow of mice.
5 Choleretic effect
Curcumin has choleretic effect. The role of curcumin has the strongest benefit in increasing the production and secretion of bile, and promoting gallbladder contraction.
6 Optical effect
The sterilization effect of curcumin is weak in the general case, but when given light irradiation, the amount of micrograms of curcumin show will show a strong phototoxic reaction. Therefore, curcumin may be used as a photosensitizer for psoriasis, cancer, bacterial and viral diseases. Curcumin can also play a stabilizing effect on the easily photolytic drugs. Such as light stabilizing effect of curcumin is particularly strong to nifedipine, which extending the half-life of nifedipine 6 times, so that the efficacy of nifedipine can be enhanced.
7 Anti-tumor effect
Turmeric extract can inhibit the growth of cancer cells. At the concentration of 0.4mg/ml, it can inhibit the growth of Chinese hamster ovary cells and has the cytotoxic effects on lymphocytes and Dalton's lymphocytes. It can also reduce the growth of animal tumors. The active ingredient of tumeric extract is mainly curcumin. Therefore, curcumin may be used as an anticancer agent.
8 Other effects
Curcumin enhances the activity of antioxidant enzyme, so it can be used for natural high-quality food additives. In addition, curcumin can increase the phagocytosis of the reticular system, regulating the body's immune function.
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